While the standard model of particle physics has been spectacularly successful in explaining various observations, it leaves open several big questions, including "What is the nature of dark matter?", "Why are some particles much heavier than others?”, and “What controls the theory at the TeV scale?” My recent work has been to explore new astrophysical constraints on the nature of dark matter, and to understand how supersymmetry could answer all three questions. I look forward to the next generation of experiments providing valuable insight into these mysteries.